Chiang broke into comics in the mid-1970s, freelancing for Marvel Comics. Her career really took off in 1981, and throughout the 1980s and up until the mid-1990s she kept extremely busy, often lettering up to ten books a month. Titles Chiang has been particularly associated with include Transformers, Visionaries, Rom, Conan the Barbarian (1982–1990), Alpha Flight (1987–1994), Iron Man (1987–1990), Ghost Rider vol. 2 (1990–1996), What If? (1990–1995), and Impulse (1999–2002).
Chiang has also worked as a comic book colorist, most notably for Guardians of the Galaxy #49–54 (1994)